Symbol: Name: ID: |
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H GFS:7176 |
Gene name: | ATP6V1H |
Chromosome: | 8q11.2 |
Previous Symbols: | |
Previous Names: | ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H |
Aliases: | CGI-11, SFD, VMA13, SFDalpha, SFDbeta |
Name Aliases: | vacuolar ATP synthase subunit H |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914864 | Rat Genome Database ID: | RGD:1562450 |
HGNC ID: | HGNC:18303 | RefSeq IDs: | NM_015941 |
Entrez Gene ID: | 51606 | Ensembl Gene ID: | ENSG00000047249 |
VEGA IDs: | OTTHUMG00000139586 | UniProt ID: | Q9UI12 |
UCSC ID: | uc003xrm.2 | OMIM ID: | 608861 |
Pubmed: | PMID9620685 PMID 10810093 | ||
CCDS IDs: | CCDSCCDS6153.1 CCDS CCDS6154.1 |
V-type proton ATPase subunit H is an enzyme that in humans is encoded by the ATP6V1H gene.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the regulatory H subunit of the V1 domain which is required for catalysis of ATP but not the assembly of V-ATPase. Three alternatively spliced transcript variants encode two isoforms of the H subunit. [provided by RefSeq, Jul 2008].
Function: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.
Products for ATP6V1H gene
Catalog | Product Name | Application | Company |
GFS:E07176 | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; ELISA kit | ELISA | n/a |
GFS:A07176 | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; Anti | ANTIBODIES | n/a |
GFS:P07176 | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; Protien | Protien | n/a |