Symbol: Name: ID: |
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 GFS:7135 |
Gene name: | ATP6V1C2 |
Chromosome: | 2p25.1 |
Previous Symbols: | |
Previous Names: | ATPase, H+ transporting, lysosomal 42kD, V1 subunit C isoform 2, "ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2" |
Aliases: | VMA5, ATP6C2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916025 | Rat Genome Database ID: | RGD:1359430 |
HGNC ID: | HGNC:18264 | RefSeq IDs: | NM_001039362 |
Entrez Gene ID: | 245973 | Ensembl Gene ID: | ENSG00000143882 |
VEGA IDs: | OTTHUMG00000090459 | UniProt ID: | Q8NEY4 |
UCSC ID: | uc002ras.2 | OMIM ID: | |
Pubmed: | PMID12384298 | ||
CCDS IDs: | CCDSCCDS1674.1 CCDS CCDS42653.1 |
V-type proton ATPase subunit C 2 is an enzyme that in humans is encoded by the ATP6V1C2 gene.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008].
Function: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Products for ATP6V1C2 gene
Catalog | Product Name | Application | Company |
GFS:E07135 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2; ELISA kit | ELISA | n/a |
GFS:A07135 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2; Anti | ANTIBODIES | n/a |
GFS:P07135 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2; Protien | Protien | n/a |