Symbol: Name: ID: |
AKTIP AKT interacting protein GFS:5807 |
Gene name: | AKTIP |
Chromosome: | 16q12.2 |
Previous Symbols: | FTS |
Previous Names: | fused toes (mouse) homolog, "fused toes homolog (mouse)" |
Aliases: | FLJ13258 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3693832 | Rat Genome Database ID: | RGD:1311170 |
HGNC ID: | HGNC:16710 | RefSeq IDs: | NM_001012398 |
Entrez Gene ID: | 64400 | Ensembl Gene ID: | ENSG00000166971 |
VEGA IDs: | OTTHUMG00000133199 | UniProt ID: | Q9H8T0 |
UCSC ID: | uc002ehl.2 | OMIM ID: | 608483 |
Pubmed: | PMID7818539 PMID 8626685 | ||
CCDS IDs: | CCDSCCDS10749.1 |
AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene.
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.
Products for AKTIP gene
Catalog | Product Name | Application | Company |
GFS:E05807 | AKT interacting protein; ELISA kit | ELISA | n/a |
GFS:A05807 | AKT interacting protein; Anti | ANTIBODIES | n/a |
GFS:P05807 | AKT interacting protein; Protien | Protien | n/a |