| Symbol: Name: ID: |
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) GFS:4922 |
| Gene name: | ARFGEF1 |
| Chromosome: | 8q13 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | DKFZP434L057, BIG1, ARFGEP1, p200 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:2442988 | Rat Genome Database ID: | RGD:1560793 |
| HGNC ID: | HGNC:15772 | RefSeq IDs: | NM_006421 |
| Entrez Gene ID: | 10565 | Ensembl Gene ID: | ENSG00000066777 |
| VEGA IDs: | UniProt ID: | Q9Y6D6 | |
| UCSC ID: | uc003xxo.1 | OMIM ID: | 604141 |
| Pubmed: | PMID10212200 PMID 8917509 | ||
| CCDS IDs: | CCDSCCDS6199.1 | ||
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP.
Products for ARFGEF1 gene
| Catalog | Product Name | Application | Company |
| GFS:E04922 | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited); ELISA kit | ELISA | n/a |
| GFS:A04922 | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited); Anti | ANTIBODIES | n/a |
| GFS:P04922 | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited); Protien | Protien | n/a |
