Symbol: Name: ID: |
BPGM 2,3-bisphosphoglycerate mutase GFS:840 |
Gene name: | BPGM |
Chromosome: | 7q31-q34 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1098242 | Rat Genome Database ID: | RGD:735018 |
HGNC ID: | HGNC:1093 | RefSeq IDs: | NM_001724 |
Entrez Gene ID: | 669 | Ensembl Gene ID: | ENSG00000172331 |
VEGA IDs: | OTTHUMG00000155380 | UniProt ID: | P07738 |
UCSC ID: | uc003vrw.2 | OMIM ID: | 222800 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS5833.1 |
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].
Plays a major role in regulating hemoglobin oxygen affinity as a consequence of controlling 2,3-BPG concentration. Can also catalyze the reaction of EC 5.4.2.1 (mutase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
Products for BPGM gene
Catalog | Product Name | Application | Company |
GFS:E00840 | 2,3-bisphosphoglycerate mutase; ELISA kit | ELISA | n/a |
GFS:A00840 | 2,3-bisphosphoglycerate mutase; Anti | ANTIBODIES | n/a |
GFS:P00840 | 2,3-bisphosphoglycerate mutase; Protien | Protien | n/a |