Symbol: Name: ID: |
U2AF1 U2 small nuclear RNA auxiliary factor 1 GFS:2246 |
Gene name: | U2AF1 |
Chromosome: | 21q22.3 |
Previous Symbols: | U2AFBP |
Previous Names: | U2(RNU2) small nuclear RNA auxiliary factor binding protein, "U2(RNU2) small nuclear RNA auxiliary factor 1" |
Aliases: | U2AF35, RNU2AF1, RN |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98884 | Rat Genome Database ID: | |
HGNC ID: | HGNC:12453 | RefSeq IDs: | NM_001025203 |
Entrez Gene ID: | 7307 | Ensembl Gene ID: | ENSG00000160201 |
VEGA IDs: | OTTHUMG00000086836 | UniProt ID: | Q01081 |
UCSC ID: | uc002zdb.1 | OMIM ID: | 191317 |
Pubmed: | PMID8660980 PMID 7956352 | ||
CCDS IDs: | CCDSCCDS13694.1 CCDS CCDS33574.1 CCDS CCDS42948.1 |
Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].
Function: Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.
Products for U2AF1 gene
Catalog | Product Name | Application | Company |
GFS:E02246 | U2 small nuclear RNA auxiliary factor 1; ELISA kit | ELISA | n/a |
GFS:A02246 | U2 small nuclear RNA auxiliary factor 1; Anti | ANTIBODIES | n/a |
GFS:P02246 | U2 small nuclear RNA auxiliary factor 1; Protien | Protien | n/a |