Symbol: Name: ID: |
XRN2 5'-3' exoribonuclease 2 GFS:2586 |
Gene name: | XRN2 |
Chromosome: | 20p11.2-p11.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:894687 | Rat Genome Database ID: | RGD:1310218 |
HGNC ID: | HGNC:12836 | RefSeq IDs: | NM_012255 |
Entrez Gene ID: | 22803 | Ensembl Gene ID: | ENSG00000088930 |
VEGA IDs: | OTTHUMG00000032025 | UniProt ID: | Q9H0D6 |
UCSC ID: | uc002wsf.1 | OMIM ID: | 608851 |
Pubmed: | PMID10409438 | ||
CCDS IDs: | CCDSCCDS13144.1 |
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.
Products for XRN2 gene
Catalog | Product Name | Application | Company |
GFS:E02586 | 5'-3' exoribonuclease 2; ELISA kit | ELISA | n/a |
GFS:A02586 | 5'-3' exoribonuclease 2; Anti | ANTIBODIES | n/a |
GFS:P02586 | 5'-3' exoribonuclease 2; Protien | Protien | n/a |