Symbol: Name: ID: |
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 GFS:866 |
Gene name: | BPNT1 |
Chromosome: | 1q42 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338800 | Rat Genome Database ID: | RGD:621833 |
HGNC ID: | HGNC:1096 | RefSeq IDs: | NM_006085 |
Entrez Gene ID: | 10380 | Ensembl Gene ID: | ENSG00000162813 |
VEGA IDs: | OTTHUMG00000037435 | UniProt ID: | O95861 |
UCSC ID: | uc001hma.2 | OMIM ID: | 604053 |
Pubmed: | PMID10224133 | ||
CCDS IDs: | CCDSCCDS41469.1 |
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq].
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Products for BPNT1 gene
Catalog | Product Name | Application | Company |
GFS:E00866 | 3'(2'), 5'-bisphosphate nucleotidase 1; ELISA kit | ELISA | n/a |
GFS:A00866 | 3'(2'), 5'-bisphosphate nucleotidase 1; Anti | ANTIBODIES | n/a |
GFS:P00866 | 3'(2'), 5'-bisphosphate nucleotidase 1; Protien | Protien | n/a |